Our current research projects

OPEL (Optimum Hospice at Home Services for End of Life Care) Phase 2 (Phase 1 completed)

Sponsor – University of Kent

A three-year mixed methods study exploring hospice at home care models including their impact on patient and carer outcomes, the costs and resource implications of patient care in different hospice at home models; experiences of patients, family carers, providers and commissioners; enablers and barriers to embedding hospice at home models.

Read about the impact of Phase 1


MEPFAC – Methylphenamide versus placebo for fatigue in advanced cancer (Phase III CTIMP; NIHR HTA funded)

Sponsor – University College London (UCL)

This study will involve patients with advanced cancer with cancer-related fatigue who are receiving palliative care.

The aim of the study is to estimate clinical effectiveness of methylphenidate versus placebo for cancer-related fatigue in patients receiving specialist palliative care.


Does acupressure help reduce nausea and vomiting in palliative care patients?

Sponsor – Gloucestershire Hospital NHS Foundation Trust

A randomised trial to determine whether acupressure at the P6 site can help in the treatment of nausea and vomiting suffered by palliative care patients.


SIP Study – Exploratory study of behaviours of patients who take their strong opioids as unmeasured sips

Sponsor – Gloucestershire Hospital NHS Foundation Trust

A prospective, observational study wherein a patient or relatives/carers are trained to use a simple scale to measure the mass of a bottle of the opioid before and after 2 doses of breakthrough strong opioid has been taken in unmeasured sips.

Our completed research and its impact


StOIC Study: An observational Study of diagnostic criteria, clinical features and management of Opioid Induced Constipation (OIC) in patients with cancer pain

Sponsor: The Royal Surrey County Hospital NHS Foundation Trust

The aim of the study is to investigate OIC in a real world/heterogeneous group of patients with cancer.

Objectives are to determine: Prevalence of OIC; Clinical features/impact of OIC; Efficacy of a treatment algorithm to manage OIC; Efficacy of conventional laxatives to manage OIC Efficacy of PAMORAs/other interventions to manage OIC.

The project consists of 2 parts: Study 1 is an observational study investigating the diagnostic criteria and clinical features of OIC. Study 2 is an observational study investigating the management of OIC (using a treatment algorithm rather than a specific intervention).


CARiAD – Carer-administration of as needed subcutaneous medication for breakthrough symptoms in home based dying patients

Sue Ryder Research Nurse will be recruiting to and delivering the study by virtue of an Honorary Contract with Gloucestershire NHS Trust.